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Karthik Chandramouli

Head of Business Development & Industry Solutions

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From Fee-for-Service Waste to Value-Based Efficiency: Rethinking Pharmacy in the VBC Era

The shift to value-based care (VBC) models represents healthcare's most significant economic transformation in decades. Yet, for many organizations, one critical aspect remains stubbornly anchored in fee-for-service thinking: pharmacy operations.

"It's the ultimate blind spot,"

explains a Chief Population Health Officer at a major ACO.

"We've redesigned care models, revamped compensation, and rebuilt analytics – but we're still approaching pharmacy decisions with a fee-for-service mindset. The result is billions in unnecessary spending and missed opportunities to optimize both cost and outcomes."

This blind spot creates a particularly painful contradiction for organizations operating under both fee-for-service and value-based models. The same decision that maximizes revenue under fee-for-service could significantly increase medical loss ratios under risk-based contracts.

The Value-Based Pharmacy Paradigm Shift

Traditional pharmacy operations focus on inventory management, dispensing efficiency, and maximizing reimbursement. Value-based pharmacy demands an entirely different approach:

  • Cost optimization vs. revenue maximization: Selecting lowest-cost therapeutically equivalent options for at-risk patients
  • Site-of-service optimization: Evaluating home infusion vs. outpatient settings based on total cost of care
  • Medication adherence: Prioritizing interventions that improve adherence and reduce downstream costs
  • Risk-stratified approaches: Applying different pharmacy protocols based on patient risk status
  • Integrated decision support: Embedding these insights at the point of care

One health system embracing this shift implemented an AI-powered pharmacy operations solution that could distinguish between fee-for-service and value-based patients at the point of care, applying different optimization criteria based on risk status.

Case Study: Same Patient, Different Economics

Consider an actual case from this health system involving a Medicare patient requiring trastuzumab (Herceptin) treatment:

Before Implementation:

  • Prescribed: Ogivri (a biosimilar)
  • Cost: $2,902 per treatment
  • Approach: Standard protocol for all patients regardless of risk arrangement

After Implementation:

  • Prescribed: Trazimera (another biosimilar in same class)
  • Cost: $1,104 per treatment
  • Approach: AI identified patient as under full-risk arrangement and recommended lowest-cost clinically equivalent option
  • Result: 62% cost reduction ($1,798 savings per infusion)

Multiplied across thousands of high-cost medication decisions annually, this type of optimization yielded projected savings of $5 million annually – with no change in clinical outcomes.

Aligning with Value-Based Care Quality Metrics

Beyond pure cost considerations, the value-based pharmacy approach directly supports key quality metrics driving VBC performance:

  1. Medication adherence metrics: By selecting medications with favorable cost-sharing for patients, adherence improved 5-8%
  2. Patient satisfaction scores: Reduced authorization delays and coverage issues improved patient experience measures
  3. Total cost of care: Lower medication costs directly impact the most significant component of medical cost ratios
  4. Hospital utilization: Fewer medication discontinuations led to reduced adverse events and hospitalizations

"What's particularly powerful is that we're simultaneously improving financial performance and quality metrics,"

notes the system's VBC Program Director.

"This isn't about denying care – it's about making smarter choices about therapeutically equivalent options that align incentives across payers, providers, and patients."

Bridging the Fee-for-Service and VBC Worlds

For organizations operating in both reimbursement models, the challenges of dual optimization are particularly acute. The AI solution deployed by this health system could:

  • Identify patient insurance and risk status in real-time
  • Apply different optimization criteria based on whether the organization bore risk
  • Show margin impact for fee-for-service patients
  • Display cost impact for at-risk patients
  • Recommend the optimal choice for each scenario

"What fascinated us was seeing the data on how often the 'right' choice differed between FFS and VBC patients,"

says the Chief Medical Officer.

"For the same medication class, the optimal selection might be completely different depending on risk arrangement. No human could possibly keep track of all those variables."

Pharmacy as a Strategic Value-Based Care Asset

As VBC continues to expand, pharmacy operations are evolving from a tactical function to a strategic asset. Organizations leading in this transformation are taking several key steps:

  1. Data integration: Combining clinical, claims, and pharmacy data for comprehensive decision support
  2. Proactive identification: Flagging high-cost medication opportunities before prescribing
  3. Real-time guidance: Embedding insights at the moment of prescribing
  4. Learning systems: Continuously updating recommendations based on outcomes and changing economics
  5. Patient engagement: Involving patients in understanding the rationale for specific medication choices

The Future of Value-Based Pharmacy

The system's experience provides a glimpse into the future of pharmacy operations in a value-based world – one where medication decisions incorporate not just clinical factors, but also economic considerations aligned with the total cost of care.

"Five years from now, we'll look back at how we used to make medication decisions and be shocked at the waste and inefficiency,"

predicts the ACO's Director of Pharmacy.

"The idea that we weren't systematically optimizing one of our largest cost centers based on risk arrangement will seem incomprehensible."

For healthcare organizations navigating the transition to value-based care, reimagining pharmacy operations represents one of the most immediate, high-impact opportunities to align clinical practice with financial incentives – and AI-powered decision support at the point of care is proving to be the key enabler of this transformation.

As one physician summarized:

"For the first time, I can make decisions that are simultaneously best for my patient, best for the healthcare system, and best for our value-based contracts. That alignment has been elusive until now."